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Effect of the tyrosine kinase inhibitor Tyrphostin A23 on the ET-1 induced constriction of permeabilized pulmonary artery rings. (A) shows a submaximal constriction to pCa 6.8, and a subsequent constriction induced by 1 μM ET-1 in the continued presence of pCa 6.8. (B) shows the effect of a 15 min pre-incubation with 100 μM Tyrphostin A23 on the constriction to pCa 6.8 and 1 μM ET-1, respectively.
