Figure 3.

Effect of 1400W on neurological deficits (a) and weight loss (b) measured 3 days after transient focal cerebral ischaemia. Treatments were started 18 h after arteries occlusion and consisted in seven subcutaneous injections at 8 h interval. Ischaemic rats were treated either with 1400W (20 mg kg⁻¹) (n=10) or vehicle (n=10). Neurological deficits (a) for the left and right paws were assessed by four neurological tests as described in Methods. Non-operated rats were used as control (n=5). The weight loss (b) was assessed as the difference before ischaemia and 3 days after reperfusion. Data are expressed as means±s.e.mean. n.s., non significant; ^*P<0.05; ^***P<0.001 versus vehicle-treated rats.