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. 1999 May;127(2):441–448. doi: 10.1038/sj.bjp.0702577

Figure 2.

Figure 2

The inhibitory effects of PD98059 and SB203580 on the IL-1 and IL-1 plus MK-571 mediated IL-6 secretion from human monocytes. (A) Percentage increase in IL-6 secretion in response to IL-1 in the absence or presence of PD98059 (10 μM) and SB203580 (1 μM) or combinations. in unstimulated monocytes IL-6 protein was <60 pg ml−1 in the presence of IL-1 (0.9±0.7 ng ml−1, x±s.d.). This was set at 100%. The following results were obtained: IL-1 plus PD98059: 37±16% (x±s.d., n=3); IL-1 plus SB 203580 24±10% and IL-1 plus PD 98059 and SB203580: 7±3%. (B) Fold induction of IL-6 secretion compared to IL-1 stimulation alone; IL-1 plus MK-571: 9.0±3.0 (x±s.d., n=3), IL-1 plus MK-571 and PD98059 2.7±0.5; IL-1 plus MK-571 and SB203580: 2.9±0.5; IL-1 plus MK-571 and PD98059/SB203580: 2.5±1.4.