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Effect of ketorolac and ibuprofen isomers on the analgesic response to acute intrathecal morphine in drug naïve animals. Ketorolac and ibuprofen were co-injected with a single dose of intrathecal morphine. The response was determined 30 min after drug injection using the (a) tailflick and (b) paw pressure tests. The data are presented as mean±s.e.mean for 4–5 animals. *Significant differences from the action of morphine/cyclodextrin (P<0.05).
