Figure 5.

Effects of nociceptin (A) and nocistatin (B) on the passive avoidance response in normal mice. Mice were treated with nociceptin (0.5–5.0 nmol mouse⁻¹, i.c.v.) (A) or nocistatin (0.5–5.0 nmol mouse⁻¹, i.c.v.) (B) 30 min before the training session, and the retention test was carried out 24 h after training. Step-down latency values are shown as median (horizontal bar), first and third quartiles (vertical column) and 10th and 90th percentiles (vertical line). Figures in parentheses show the numbers of mice used. ^**P<0.01 vs control (Bonferroni's test).