Figure 6.

Effects of nociceptin (A) and nocistatin (B) on scopolamine-induced impairment of the passive avoidance response. Mice were treated with scopolamine (0.1 μmol kg⁻¹, s.c.) and nociceptin (0.5–5.0 nmol mouse⁻¹, i.c.v.) (A) or nocistatin (0.5–5.0 nmol mouse⁻¹, i.c.v.) (B) 30 min before the training session, and the retention test was carried out 24 h after training. Step-down latency values are shown as median (horizontal bar), first and third quartiles (vertical column) and 10th and 90th percentiles (vertical line). Figures in parentheses show the numbers of mice used. ^**P<0.01 vs control for scopolamine alone (Mann-Whitney U-test), #P<0.05 vs scopolamine alone (Bonferroni's test).