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. 1999 Jun;127(3):693–700. doi: 10.1038/sj.bjp.0702608

Figure 2.

Figure 2

Effects of ODQ on SNAP-induced increases in cyclic GMP levels in aortic rings and cardiomyocytes. (a) Cyclic GMP levels in aortic rings with intact endothelium. The cyclic GMP levels (in pmol mg−1 protein) were 15.3±0.9 (n=25) under control conditions, 58.8±4.1 (n=12) in the presence of SNAP (100 μM), 10.5±1.7 (n=11) in the presence of both ODQ (50 μM) and SNAP (100 μM), 27.6±2 (n=10) in the presence of both carboxy-PTIO (500 μM) and SNAP (100 μM), 6.8±1.7 (n=10) in the presence of ODQ (50 μM) alone, and 2.3±0.9 (n=7) in the presence of carboxy-PTIO (500 μM) alone. (b) Cyclic GMP levels in isolated cardiomyocytes. The cyclic GMP levels (in pmol/mg protein) were 6±0.3 (n=45) under control conditions, 13.4±1.4 (n=15) in the presence of SNAP (100 μM), 13±1.1 (n=12) in the presence of both ODQ (50 μM) and SNAP (100 μM), 8.6±0.9 (n=9) in the presence of both carboxy-PTIO (500 μM) and SNAP (100 μM), 6.5±0.5 (n=12) in the presence of ODQ (50 μM) alone, and 5.6±0.9 (n=6) in the presence of carboxy-PTIO (500 μM) alone. Columns represent means±s.e.mean. Statistically significant differences (P<0.05) are marked by *.