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. 1999 Jun;127(3):693–700. doi: 10.1038/sj.bjp.0702608

Figure 3.

Figure 3

Effects of ODQ on DETA NONOate-induced increases in cyclic GMP levels in aortic rings and cardiomyocytes. (a) Cyclic GMP levels in aortic rings with intact endothelium. The cyclic GMP levels (in pmol mg−1 protein) were 15.3±0.9 (n=25) under control conditions, 47.1±2.7 (n=9) in the presence of DETA NONOate (100 μM), 3.2±1.2 (n=6) in the presence of ODQ (50 μM) and DETA NONOate (100 μM), and 5.8±0.1 (n=6) in the presence of carboxy-PTIO (500 μM) and DETA NONOate (100 μM). (b) Cyclic GMP levels in isolated cardiomyocytes. The cyclic GMP levels (in pmol mg−1 protein) reached 6±0.3 (n=45) under control conditions, 11.9±1.5 (n=9) in the presence of DETA NONOate (100 μM), 11.5±2.4 (n=9) in the presence of ODQ (50 μM) and DETA NONOate (100 μM), and 6.9±1 (n=9) in the presence of carboxy-PTIO (500 μM) and DETA NONOate (100 μM). Columns represent means±s.e.mean. Statistically significant differences (P<0.05) are marked by *.