Figure 6.

Effects of ODQ on SNAP-induced increases in cyclic GMP levels in cytosolic extracts from aortic rings and cardiomyocytes. (a) Cyclic GMP levels in extracts from aortic rings. The cyclic GMP levels (in pmol mg⁻¹ protein) were 212±50 (n=9) under control conditions, 200±70 (n=6) in the presence of ODQ (50 μM), 12600±1500 (n=6) in the presence of SNAP (100 μM), and 6800±1000 (n=6) in the presence of both ODQ (50 μM) and SNAP (100 μM). (b) Cyclic GMP levels in extracts from cardiomyocytes. The cyclic GMP levels (in pmol mg⁻¹ protein) were 3.4±0.3 (n=18) under control conditions, 4±1.2 (n=6) in the presence of ODQ (50 μM), 258±13 (n=12) in the presence of SNAP (100 μM), and 138±9 (n=12) in the presence of both ODQ (50 μM) and SNAP (100 μM). Columns represent means±s.e.mean. Statistically significant differences (P<0.05) are marked by ^*.