Skip to main content
. 1999 Jun;127(3):717–728. doi: 10.1038/sj.bjp.0702620

Figure 1.

Figure 1

Time-course effects on changes in mean arterial pressure (ΔMAP) and heart rate (ΔHR) of [Sar9, Met(O2)11)]SP injected i.c.v. at 10 (n=9), 25 (n=9), 65 (n=8) and 100 (n=8) pmol per animal and septide injected i.c.v. at 10 (n=12), 25 (n=9), 65 (n=6) and 100 (n=6) pmol per animal for a period of 30 min post-injection in conscious rats. Basal values were: MAP: 107±3 mmHg: HR 395±10 beats min−1 for [Sar9, Met(O2)11]SP and MAP: 107±3 mmHg; HR: 400±8 beats min−1 for septide. Statistical significance of differences between vehicle (n=18) and [Sar9, Met(O2)11]SP or septide values were calculated with a two-way ANOVA followed by a Dunnett's test and are indicated by: *P<0.05; **P<0.01.