Skip to main content
. 1999 Jun;127(4):935–940. doi: 10.1038/sj.bjp.0702636

Figure 3.

Figure 3

WIN55,212-2 decreases the frequency of spontaneous mIPSCs. (a) Time course of mIPSC rate during superfusion of met-enkephalin (10 μM, ME) and addition of naloxone (1 μM, Nalx), then during superfusion of WIN55,212-2 (3 μM, WIN) and addition of SR141716 (3 μM, SR). Recordings were carried out in the presence of CNQX (3 μM) and TTX (0.3 μM). (b) Raw current traces of mIPSCs before (Control) and during superfusion of met-enkephalin (ME) and WIN55,212-2 (WIN), then after addition of SR141716 (SR). (c) Averaged traces of mIPSCs before and during superfusion of met-enkephalin and WIN55,212-2, then after addition of SR141716 (number of events=778, 523, 434, 766 for 120 s epochs of Control, ME, WIN and SR, respectively). (d) Probability density distributions (bin width=20 pA) of mIPSC amplitude for the epochs indicated in (c). (a–d) are taken from one neuron.