Figure 5.

The effect of the Ca²⁺ channel antagonist diltiazem on agonist induced contractions of human detrusor human smooth muscle. (A) Shows sections of original records from a single experiment. Where indicated carbachol at a concentration of either 0.1 μM (1) or 10 μM (2) was added to the superfusion solution. Also, where shown, diltiazem (10 μM) was added. Ordinate shows force produced by the muscle strip (mN) and the abscissa, time in s. All experiments were done at 35–37°C. (B) Illustrates data from four separate experiments presenting mean data of the amplitudes of contractions at two doses of carbachol in the absence (open bars) and presence (filled bars) of diltiazem (10 μM). Error bars show s.e. mean.