Figure 3.
The effect of 12-deoxyphorbol 13-substituted mono-esters on the fractional stimulation-induced (S-I) outflow of radioactivity from rat cortex slices pre-incubated with [3H]-serotonin. There were four periods of electrical stimulation (each 1 Hz for 60 s) and drugs (dPA; dPAng; dPiB; dPT; dPPhen) were present during the second, third and fourth stimulation in increasing concentrations. All results are expressed as described in Figure 1 legend. Each symbol represents the mean and the vertical lines the standard error of the mean (s.e.mean). The number of experiments was between 4–8 for each drug. *Represents a significant difference from control, (P<0.05, Scheffé's test after two-way ANOVA).