Figure 3.

Fluorescence micrographs of PAR₂-immunoreactivity in the rat paw from animals injected 6 h earlier with a control peptide (LS-NH₂, A and C) and paws injected with a PAR₂AP (tc-NH₂, B and D). (A) Subdermis from the control paw showing little or no specific labelling. (B) In paws injected with the PAR₂AP, there was an extensive infiltration of immunoreactive cells and considerable oedema. (C) On the endothelium of some blood vessels of control tissues (arrow) there was faint PAR₂-immunoreactivity. (D) In PAR₂AP-treated paws, increased intensity of PAR₂-immunoreactivity was found on the endothelium of some blood vessels (mostly venules, arrow). Scale bars: 50 μm. The scale bar in B is for A and B, and the bar in D is for C and D.