Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1999 Jul;127(5):1213–1223. doi: 10.1038/sj.bjp.0702642

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 1999, Nature Publishing Group

PMC Copyright notice

Effect of 0.1 μM E-4031 on the fast and slow component of the deactivation current. (A) Original currents at −45 mV in control and in 0.1 μM E-4031 applied for 4 min. Holding potential −20 mV, cell diameter 64 μm, temperature 33°C. Double exponential fits with eq (1) superimposed, starting 16 ms after beginning of pulse. Fit parameters:
(B) Inhibition of K1 (=initial amplitude of slow component) and K3 (=initial amplitude of fast component) at −55 mV plotted against concentration of E-4031; n=3–5 per point. Values for K1 fitted with dose-response curve. Parameters: Maximum inhibition=82.5%, IC₅₀=38.1 nM, Hill coefficient=1.70.

graphic file with name 127-0702642e6.jpg — Effect of 0.1 μM E-4031 on the fast and slow component of the deactivation current. (A) Original currents at −45 mV in control and in 0.1 μM E-4031 applied for 4 min. Holding potential −20 mV, cell diameter 64 μm, temperature 33°C. Double exponential fits with eq (1) superimposed, starting 16 ms after beginning of pulse. Fit parameters:
(B) Inhibition of K1 (=initial amplitude of slow component) and K3 (=initial amplitude of fast component) at −55 mV plotted against concentration of E-4031; n=3–5 per point. Values for K1 fitted with dose-response curve. Parameters: Maximum inhibition=82.5%, IC₅₀=38.1 nM, Hill coefficient=1.70.