Figure 1.

Bronchial responsiveness to acetylcholine in sensitized Brown Norway rats exposed repeatedly to saline or ovalbumin. There was a half-log order decrease in the mean −log PC₂₀₀ value in repeatedly allergen-exposed rats compared to the saline-exposed group (#P<0.05). Following repeated allergen exposure, treatment with SB 210661, SB 201146 or pranlukast caused no significant attenuation of mean −log PC₂₀₀ values compared to vehicle-treated rats. Data are expressed as mean −log PC₂₀₀ values with error bars representing 95% confidence intervals.