Figure 4.

The incidence of ventricular fibrillation during coronary artery occlusion and following reperfusion at the end of the 25 min occlusion in control dogs (SC), in dogs subjected to right ventricular pacing 24 h prior to the occlusion (SP24) and in paced (SP24+AG) and non-paced (AG+occl.) dogs given aminoguanidine (AG) 0.5 h prior to coronary artery occlusion. Also shown in the right hand panels is survival from the combined ischaemia-reperfusion insult. The marked protection against ventricular fibrillation during both occlusion and reperfusion which results from cardiac pacing is markedly attenuated by the prior administration of aminoguanidine. ^*P<0.05 compared to sham controls; †P<0.05 compared to paced dogs given aminoguanidine.