Figure 3.

Effect of CP-96,345 (a), CP-99,994 (b), sendide (c) and [D-Phe⁷, D-His⁹]SP (6–11) (d) on nociceptin-induced scratching, biting and licking response in mice. Each antagonist was co-administered i.t. with nociceptin (3.0 fmol) in a total volume of 5 μl. The duration of scratching, biting and licking induced by nociceptin was determined over a 20 min period starting immediately after injection. Each value represents the mean±s.e.mean of ten mice in each group. ^*P<0.05, ^**P<0.01 when compared with corresponding CSF-controls ((a) 97.2±14.9 s; (b) 94.1±11.0 s; (c) 94.0±15.5 s; (d) 94.0±14.0 s).