Figure 3.

Inhibitory effects of glaucine on different functional responses of human polymorphonuclear leukocytes (PMN). Superoxide generation was obtained in cells stimulated by N-formyl-Met-Leu-Phe (FMLP), phorbol myristate acetate (PMA), serum-opsonized zymosan (SOZ), and calcium ionophore A23187. In addition, FMLP elicited elastase release, leukotriene B₄ (LTB₄) production, and an intracellular [Ca²⁺]_i signal (assessed as AUC_1–5 min). Platelet aggregation was produced by FMLP in a PMN-platelet system after activation with FMLP. Data are derived from 5–6 PMN preparations from different individuals and data are given as mean±s.e.mean.