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Relaxations to ACh in isolated endothelium-intact mesenteric arterial rings from normotensive and hypertensive subjects. The relaxations were induced after precontraction with 1 μM noradrenaline in the absence and presence of 3 μM diclofenac; in the presence of diclofenac and 0.1 mM NG-nitro-L-arginine methyl ester (L-NAME); and in the presence of diclofenac, L-NAME and 1 μM apamin. Symbols indicate mean±s.e.mean, n=20–22 in the normotensive and 15–17 in the hypertensive group.
