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Acid secretion stimulated by pentagastrin (100 μg kg−1, i.p., 0.25 ml) in the perfused stomach of the rat was reduced by the microinjection of bombesin in the PvN of the hypothalamus (12 ng kg−1). Microinjection of L-NAME (80 μg kg−1) into the DMN prevented the acid-inhibitory effects of bombesin injected in the PvN. Each bar represents mean±s.e.mean of at least five animals and significant difference from the control group is shown by *P<0.05 and from the bombesin group by +P<0.05.
