Figure 4.
Terodiline enhances frequency-dependent reduction of ICa,L and slows recovery of the current from inactivation. Myocytes were bathed and dialysed with K+ solutions, and pulsed at a basic rate of 0.1 Hz. (a) Records illustrating the reduction of ICa,L induced by 3-Hz trains of 25 pulses before and 6 min after addition of 5 μM terodiline. (b) Time courses of recovery of ICa,L from 200-ms inactivating pulses before and ca. 5 min after addition of 3 μM terodiline. The exponential fitting the control data (n=10 myocytes) has τ=82 ms. A point-to-point line is used to connect the terodiline data since they are poorly described by a single exponential (c) Recovery from inactivation in four myocytes held at −35 mV and treated with 10 μM terodiline.