Figure 3.

Inhibition of forskolin stimulated (10 μM) short-circuit current in porcine thyroid epithelial cell monolayers cultured on permeable supports in Transwell Ussing chambers by purines and pyrimidines. Data shown are cumulative dose response curves of the depression of short-circuit current expressed as a per cent of the total phenamil sensitive current (1 μM) (see Figure 2); means±s.e.mean (n=5–10). Compounds used were uridine 5′-triphosphate (UTP); uridine 5′-diphosphate (UDP); adenosine 5′-triphosphate (ATP); 2-methyl-thio-adenosine-5′-triphosphate (2MeSATP); adenosine 5′-diphosphate (ADP); α,β-methylene adenosine triphosphate (α,β-MeATP).