TABLE 2.
Comparison of Prairie and Meadow Voles: CRFR2 Binding Using 125-I-Sauvagine and CP-154,5261
| Region | Abbreviation | Meadow Female Mean ± SEM | Meadow Male Mean ± SEM | Prairie Female Mean ± SEM | Prairie Male Mean ± SEM |
|---|---|---|---|---|---|
| Cortical | |||||
| Prefrontal | PFCtx | 3117 ± 83 | 3180 ± 112 | 2957 ± 78 | 2862 ± 123 |
| Insular | IFCtx | 2937 ± 79 | 2906 ± 74 | 2906 ± 57 | 2884 ± 121 |
| Orbitofrontal | OFCtx | 2845 ± 125 | 2805 ± 79 | 2809 ± 30 | 2828 ± 77 |
| Cingulate rostral | CgCtx1 | 3331 ± 150 | 3195 ± 153 | 3000 ± 67 | 2924 ± 66 |
| Cingulate middle | CgCtx2 | 3066 ± 121 | 2905 ± 206 | 2842 ± 81 | 2955 ± 81 |
| Cingulate caudal | CgCtx3 | 3007 ± 34 | 2918 ± 153 | 2832 ± 60 | 2858 ± 110 |
| Retrosplanial | RSCtx | 2846 ± 170 | 3305 ± 321 | 2660 ± 89 | 2768 ± 186 |
| Septal-hippocampal | |||||
| Lateral septum | LS | ||||
| dorsal rostral | rLSD | 5974 ± 475 | 6116 ± 572 | 4449 ± 298 | 4211 ± 579 |
| intermediata rostral | rLSl | 8306 ± 912 | 6662 ± 552 | 5830 ± 649 | 5583 ± 1138 |
| dorsal caudal | cLSD** | 6896 ± 604 | 6776 ± 602 | 4444 ± 182 | 4274 ± 485 |
| intermediata caudal | cLSI | 12374 ± 1601 | 9357 ± 747 | 7888 ± 1213 | 7635 ± 2000 |
| Hippocampus | HC | ||||
| CA1 | CA1** | 8534 ± 630 | 10404 ± 808 | 3598 ± 156 | 3978 ± 268 |
| CA2 | CA2** | 3727 ± 186 | 3763 ± 300 | 2830 ± 53 | 2832 ± 246 |
| CA3 | CA3** | 3332 ± 136 | 3339 ± 255 | 2656 ± 61 | 2735 ± 159 |
| dentate gyrus | DG | 4826 ± 727 | 4571 ± 494 | 2924 ± 88 | 2951 ± 166 |
| Extended amygdala | |||||
| Bed nucleus of the stria terminals | BnST | ||||
| medial | mBnST | 2638 ± 96 | 2650 ± 122 | 2437 ± 38 | 2559 ± 73 |
| lateral | lBnST | 2503 ± 45 | 2503 ± 98 | 2442 ± 36 | 2501 ± 84 |
| caudal | cBnST† | 4154 ± 302 | 14671 ± 861 | 2563 ± 109 | 6214 ± 541 |
| Amygdala | Amyg | ||||
| central | CeA | 2412 ± 78 | 2504 ± 105 | 2410 ± 91 | 2514 ± 84 |
| basolateral rostral | rBLA | 2846 ± 84 | 2916 ± 118 | 3379 ± 243 | 3050 ± 161 |
| medial rostral | rMeA | 2613 ± 40 | 2724 ± 121 | 2960 ± 171 | 3091 ± 197 |
| cortical rostral | rCoA | 2988 ± 107 | 3117 ± 122 | 2797 ± 129 | 2839 ± 68 |
| basolateral caudal | cBLA | 2817 ± 61 | 2679 ± 91 | 3154 ± 248 | 2982 ± 159 |
| medial caudal | cMeA | 2722 ± 105 | 3015 ± 197 | 3150 ± 155 | 3250 ± 257 |
| cortical caudal | cCoA | 3144 ± 104 | 3240 ± 194 | 2630 ± 57 | 2746 ± 133 |
| Striatum and habenula | |||||
| Nucleus accumbens | NAcc | ||||
| shell | shNAcc | 2823 ± 60 | 2804 ± 176 | 2922 ± 132 | 2822 ± 90 |
| septal pole | spNAcc** | 3258 ± 210 | 2969 ± 228 | 6981 ± 641 | 6185 ± 703 |
| Caudate-putamen | CPu | ||||
| dorsal | CPuD | 2503 ± 62 | 2381 ± 111 | 2594 ± 153 | 2700 ± 136 |
| ventral | CPuV** | 2812 ± 51 | 2572 ± 145 | 4738 ± 520 | 4740 ± 421 |
| Habenula | |||||
| medial | mHab | 2704 ± 20 | 2818 ± 131 | 2716 ± 47 | 2611 ± 131 |
| lateral | lHab | 2645 ± 40 | 2683 ± 145 | 2469 ± 67 | 2477 ± 97 |
| Thalamus | |||||
| laterodorsal | ldThal | ND | ND | ND | ND |
| Olfactory and hindbrain | |||||
| Olfactory bulb | |||||
| external plexiform | OB | 2909 ± 97 | 3040 ± 45 | 3060 ± 30 | 3053 ± 191 |
| Superior colliculus | SColl | 2938 ± 129 | 3116 ± 174 | 2725 ± 77 | 2799 ± 149 |
| Periaqueductal gray | PAG | 2482 ± 51 | 2548 ± 80 | 2407 ± 69 | 2408 ± 166 |
| Dorsal raphe | DR | 7047 ± 740 | 8852 ± 981 | 8694 ± 1672 | 7250 ± 1372 |
| Locus coeruleus | LC | 2843 ± 138 | 2591 ± 100 | 2989 ± 189 | 2591 ± 181 |
| Pontine dorsal tegmental nucleus | PDTg | 2451 ± 32 | 2473 ± 106 | 3154 ± 203 | 2950 ± 223 |
| Principal motor nucleus of 5 | Pr5 | 3791 ± 160 | 3499 ± 237 | 4959 ± 470 | 5433 ± 952 |
| Cerebellum | |||||
| granular layer | CBg | 2689 ± 78 | 2751 ± 147 | 2807 ± 125 | 2631 ± 127 |
1
Values represent mean DPM/mg tissue from n = 4 per group.
ND, not detected (<2 S.D. nonspecific binding);
*
P < 0.05 species effect;
**
P < 0.01 species effect;
†
P < 0.05 sex effect.