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. Author manuscript; available in PMC: 2006 Sep 14.
Published in final edited form as: J Comp Neurol. 2005 Jun 20;487(1):75–92. doi: 10.1002/cne.20532

TABLE 5.

Relative Comparison of CRFR1 Binding across Six Species: Semiquantitative Analysis

Region Meadow Prairie Montane Pine Rat1 Monkey2
Cortex ++++ ++++ ++ ++ ++++ ++++
Cerebellum +++ +++ ++ ++ +++ ++++
Olfactory bulb +++++ ++++ +++++ +++ +++ nr
Superior colliculus +++++ ++++ ++++ + ++ nr
Lateral septum ++ ++ ++++ ++++ 0 0
Hippocampus 0 0 0 0 ++ ++++
Amygdala +/++ + + 0/+ +++ ++++
Periaqueductal gray + + 0 0 ++++ nr
Habenula ++ ++++ 0 0 0 nr
Laterodorsal thalamus 0 0 ++ 0 ++ nr
Locus coeruleus + + + 0 0 +++
Dorsal raphe 0 0 ++ ++++ ++ 0
Nucleus accumbens, shell +++ 0/+ +++ 0 ++ nr
1

Rat data are compiled from meta-analysis of CRFR1 receptor binding reports from de Souza et al. (1985), de Souza et al. (1987), Primus et al. (1997), and Steckler and Holsboer (1999).

2

Monkey data are summarized from Sanchez et al. (1999) and Grigoriadis et al. (1995).

For vole data, averaged across sex: 0, <1000 dpm/mg; +, 1000–2000 dpm/mg; ++, 2000–4000 dpm/mg; +++, 4000–6000 dpm/mg; ++++, 6000–10000 dpm/mg; +++++, >10000 dpm/mg; nr, not reported.