TABLE 6.
Relative Comparison of CRFR2 Binding across Six Species: Semiquantitative Analysis
Region | Meadow | Prairie | Montane | Pine | Rat1 | Monkey2 |
---|---|---|---|---|---|---|
Choroid plexus | +++++ | +++++ | +++++ | +++++ | +++++ | +++++ |
Dorsal raphe | ++++ | ++++ | ++++ | +++++ | +++ | ++ |
Olfactory bulb | ++ | ++ | + | ++ | +++ | nr |
Cortex | ++ | ++ | + | + | + | + |
Amygdala | ++ | ++ | + | + | +++ | +++ |
Periaqueductal gray | ++ | ++ | 0/+ | + | + | nr |
Locus coeruleus | ++ | ++ | 0/+ | + | 0 | 0 |
Cerebellum | ++ | ++ | 0/+ | + | 0 | 0 |
Lateral septum | ++++ | +++ | ++++ | +++++ | ++++ | + |
Hippocampus | ++++ | ++ | + | + | + | +++ |
Laterodorsal thalamus | 0 | 0 | ++++ | 0/+ | 0 | nr |
Superior colliculus | ++ | ++ | + | + | 0 | nr |
Nucleus accumbens, septal pole | ++ | ++++ | + | +++++ | 0 | nr |
Rat data are compiled from meta-analysis of CRFR2 receptor binding reports from de Souza et al. (1987), Primus et al. (1997), Rominger et al. (1998), and Steckler and Holsboer (1999).
Monkey data are summarized from Sanchez et al. (1999) and Grigoriadis et al. (1995).
For vole data, averaged across sex: 0, <1000 dpm/mg; +, 1000–2000 dpm/mg; ++, 2000–4000 dpm/mg; +++, 4000–6000 dpm/mg; ++++, 6000–10000 dpm/mg; +++++, > 10000 dpm/mg; nr, not reported.