Table 2.

Anticonvulsant effect of carbenoxolone against seizure induced by maximal electroshock in mice

Treatment	Dose	Duration of tonic seizure (sec)	Seizure protection (%)	Mortality protection (%)
Normal saline	10 ml/kg	17.57 ± 1.72	0	14.28
Diazepam	0.25 mg/kg	11.8 ± 0.48**	0	100
	0.5 mg/kg	8.63 ± 0.21***	0	100
	3 mg/kg	6.06 ± 1.27***	14.3	100
Carbenoxolone	100 mg/kg	12.11 ± 2.28	14.3	85.7
	200 mg/kg	12.10 ± 2.04	14.3	87.7
	300 mg/kg	11.85 ± 1.61	14.3	60
	400 mg/kg	9.16 ± 1.71*	28.6	14.28

Carbenoxolone and diazepam (i.p.) were injected 60 and 30 minutes respectively, before the induction of maximal electroshock seizures, respectively. Values are the mean ± SEM for 7 mice. *P < 0.05, ***P < 0.001, Compared to control, Tukey-Kramer Test.