Fig. 1. NMD3 is conserved between Eukarya and Archaea. (A) Schematic diagram showing the conserved nature of the eukaryotic NMD3 proteins. This alignment was made using MACAW. Blocks of amino acid similarities are indicated by wide boxes, and positions of identity among all four sequences are indicated by vertical bars. (B) Sequence alignment of the C-terminal domains of Homo sapiens (Hs), Drosophila melanogaster (Dm), Saccharomyces cerevisiae (Sc) and Arabidopsis thaliana (At) NMD3 proteins. Conserved (black) and similar (gray) amino acid residues are indicated. NLS and NES indicate the regions resembling a basic nuclear localization signal and a leucine-rich nuclear export signal, respectively. Accession numbers are: Hs (ADD27716), Dm (AE003423.1), At (AAD24816) and Sc (S48909).