Fig. 4. Similarity of C.albicans genes that affect filamentous growth to genes in S.cerevisiae. (A) Roughly two-thirds of the C.albicans genes identified in the screen for filamentous growth mutants have closely related genes in S.cerevisiae. Nearly 30% lack significant similarity (as indicated by a BLAST score less than –15) to genes in any available databases. (B) The overall distribution of C.albicans genes relative to the S. cerevisiae genome. (C) Putative functions for the C.albicans genes that affect filamentous growth and have a close relative in S.cerevisiae. Each of these C.albicans genes was assigned a function based on the S.cerevisiae counterpart (see Supplementary table 1 for individual assignments). Categories are derived from the Saccharomyces Genome Database (http://genome-www.stanford.edu/Saccharomyces/).