Fig. 9. Electrostatic potential surface representation of Mona/Gads SH3C with molecular models of different well characterized SH3 domain binding peptides docked onto the SH3 domain. The peptides were aligned through structural superposition of their respective SH3 partners onto the present structure. (A) Comparison of the SLP-76 peptide (P2, dark green) with a C3G peptide (light green) from the mouse c-Crk SH3N–C3G complex (1CKA.pdb). (B) Comparison of the SLP-76 peptide (dark green) with an mSos peptide (light green) from the Sem-5 SH3C complex (1SEM.pdb).