Fig. 5.
Dependence of vesicle fusion rates on crosslinker length. To assess the effect of crosslinker length on vesicle fusion rates, the fraction of vesicles that have mixed outer leaflets is plotted as a function of time for crosslinker lengths of 1, 2, 4, and 6 nm. Simulations with a crosslinker length of 2 nm have a t1/2 of 80 ns for outer leaflet mixing, compared with 20 ns for simulations with a 1-nm crosslinker. Simulations with crosslinker lengths of 4 and 6 nm remain at <50% fused after 150 ns. Dashed lines represent one standard deviation of the mean.