Table 1.

Peripheral insulin effects in lean and obese subjects (hyperinsulinemic euglycemic clamp)

Time period	Steady-state plasma glucose, mmol/liter		Steady-state plasma insulin, pmol/liter		Glucose infusion rate, μmol·kg−1·min−1		Insulin sensitivity, μmol·kg−1·min−1·pmol−1·liter
	Lean	Obese	Lean	Obese	Lean	Obese	Lean	Obese
Basal	4.68 ± 0.08	4.75 ± 0.10	38 ± 3	70 ± 10*	–	–	–	–
First step	5.13 ± 0.09	5.00 ± 0.09	79 ± 6	149 ± 16†	9.6 ± 1.2	5.5 ± 0.6†	0.12 ± 0.01	0.04 ± 0.01‡
Second step	4.87 ± 0.08	4.60 ± 0.10	351 ± 23	547 ± 43†	44.8 ± 4.0	23.4 ± 2.7‡	0.13 ± 0.01	0.06 ± 0.01‡

∗, P < 0.05;

†, P < 0.01;

‡, P < 0.001.