Table 3.

Peripheral insulin effects in IRS-1 Gly/Gly and X/Arg subjects (hyperinsulinemic euglycemic clamp)

Time period	Steady-state plasma glucose, mmol/liter		Steady-state plasma insulin, pmol/liter		Glucose infusion rate, μmol·kg−1·min−1		Insulin sensitivity, μmol·kg−1·min−1pmol−1·liter
	Gly/Gly	X/Arg	Gly/Gly	X/Arg	Gly/Gly	X/Arg	Gly/Gly	X/Arg
Basal	4.73 ± 0.06	4.50 ± 0.17	47 ± 5	41 ± 10	–	–	–	–
First step	5.09 ± 0.09	5.12 ± 0.13	97 ± 12	119 ± 18	7.8 ± 1.1	7.5 ± 1.1*	0.10 ± 0.02	0.08 ± 0.02†
Second step	4.72 ± 0.08	4.88 ± 0.19	424 ± 32	406 ± 40	39.3 ± 5.0	29.8 ± 3.9‡	0.10 ± 0.02	0.09 ± 0.02§

∗, P = 0.86;

†, P = 0.44;

‡, P = 0.24;

§, P = 0.56.