Table 1.

¹H NMR-derived metabotypes significantly associated with the response of BALB/c and 129S6 mice to dietary intervention at 5 months of age

Biomarkers OPLSDA coef	δ, ppm	BALB/c LFD	BALB/c HFD	129S6 LFD	129S6 HFD
PC (p)	3.219	−0.24	0.71	−0.43	−0.07
Choline (u)	3.203	−0.28	0.56	−0.26	0.09
TMA (u)	2.892	−0.28	0.20	−0.41	0.70
TMAO (u)	3.2705	−0.35	0.14	−0.39	0.83
DMA (u)	2.728	−0.27	0.30	−0.49	0.69
MMA (u)	2.77	−0.26	0.23	−0.47	0.72
DMG (u)	2.93	0.81	−0.14	−0.40	−0.33
Creatine (u)	3.0405	0.69	−0.42	0.06	−0.51
Glycerate (u)	4.0975	−0.52	−0.50	0.81	0.09
Gluratate (u)	1.792	−0.18	−0.48	0.84	−0.39
Isovalerate (u)	2.19	−0.41	−0.47	0.88	−0.17
Pyruvate (u)	2.347	−0.15	0.81	−0.50	0.00

The OPLSDA model coefficients are listed for each of the models reported in Fig. 2. For each metabolite, we report the chemical shift δ (in parts per million) and the OPLSDA-derived correlation (coef) for each class in the model: BALB/c LFD, BALB/c HFD, 129/S6 LFD, and 129/S6 HFD. A positive (negative) correlation means a higher (lower) intensity of the NMR resonance of the metabolite significantly associated to the corresponding class. (p), plasma; (u), urine.