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Expression and function of the AKAR2 in neonatal rat cardiac myocytes. (A) Schematic of AKAR2, with FRET from cyan fluorescent protein (CFP) to yellow fluorescent protein (YFP) upon phosphorylation by PKA leading to an increase in yellow/cyan emission ratio. (B) Expression and cytosolic distribution of AKAR2 in a neonatal rat cardiac myocyte. (Scale bar: 25 μm.) (C) AKAR2 emission ratios with 50 μM DMNB-caged cAMP (5-s UV activation) followed by 0.1 μM Iso.
