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Model predictions of mechanisms contributing to PKA-mediated phosphorylation gradients. (A and B) Sensitivity of predicted gradient magnitude (ΔRP/ΔRD) (A) and propagation time (ΔtMAX) (B) to variation in DcAMP, where dashed lines are experimental means from Fig. 4C. (C) Comparison of predicted gradients (ΔRP/ΔRD) for the baseline model (DcAMP = 200 μm2/s, as in Fig. 5) and several model perturbations that test mechanisms contributing to PKA-mediated phosphorylation gradients.
