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Dose–response curve of the AT-III sensor for the heparin-based pentasaccharide drug fondaparinux (●) and 6-O-desulfated fondaparinux (○), which is known to exhibit low binding affinity for AT-III. Data points for fondaparinux are fit with a Langmuir isotherm (solid line), and those for 6-O-desulfated fondaparinux are connected with a dashed line.
