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. 2006 Aug 28;103(36):13468–13473. doi: 10.1073/pnas.0600655103

Fig. 2.

Fig. 2.

Optimization of adenoviral transduction conditions to target the mouse islet periphery and induce islet GLP-1 secretion. (A and B) Ad5lacZ was used to optimize transduction conditions such that the islet periphery was transduced in isolated islets. Transduced cells appear blue; glucagon-positive cells appear brown. (C) PC1/3 immunoreactivity in mouse islets 72 h after treatment with AdPC1/3. (Scale bars: A, 250 μm; B and C, 100 μm.) (D) GLP-1 secretion by mouse islets 72 h after treatment with AdPC1/3. Data were analyzed by using one-way ANOVA; ∗ ∗ ∗, P < 0.001 compared with moi = 0; n = 3.