Fig. 4.

AdPC1/3 transduction improves islet transplantation outcomes in STZ-treated mice. STZ-treated diabetic mice received subcapsular transplant of mock- (control) or AdPC1/3-transduced (moi = 10) islets on day 0 and nephrectomy (Nx) on day 21. (A) Blood glucose levels in transplant recipients (n = 4). (B) Blood glucose normalization curves for transplant recipients, expressed as percentage of animals normalized. The day of normalization was considered the second of ≥2 consecutive days where blood glucose was <15 mM. (C) i.p. glucose tolerance test (2 g/kg) performed 5 d after transplantation. Data were analyzed by using a two-tailed t test. ∗, P < 0.05; ∗ ∗, P < 0.01.