Table 1.

Four different studies showing that between 40% to 70% of previously untreated NPC specimens have loss of p16 expression.

Investigators	Number of NPC specimens examined	Percent of NPC with loss of p16 staining
Hwang et al [13]	65	65%
Makitie et al [16]	84	70%
Huang et al [15]	74	42%
Baba et al [14]	20	40%
Lin et al [this study]	27	96%

This is in contrast to the 96% of recurrent NPC found in this study to have loss of p16 expression.