Table 2.

Minimum number of class I, II and II CIN genes (n₁, n₂ and n₃, respectively) required for emergence of CIN before the inactivation of the first tumour suppressor gene (TSG). (The relative fitness value of CIN cells is denoted by r. Parameter values are N₀=4, u=10⁻⁷, p₀=10⁻⁶, p=10⁻², τ₀=10 days and τ₁=1 day.)

CIN before 1 TSG				CIN before 2 TSGs
	independent of N1			N1=104			N1=105
r	n1	n2	n3	n1	n2	n3	n1	n2	n3
1.0	2	12	89	1	1	16	1	2	37
0.9	2	14	96	1	1	17	1	3	41
0.5	4	42	169	1	2	35	1	8	74