Table 3.
Percentage of tumours initiated by inactivation of one or two tumour suppressor genes (TSGs) in which CIN emerges before the inactivation of the first TSG.(The number of class I, II and III CIN genes is given by n1, n2 and n3, respectively. The relative fitness value of CIN cells is denoted by r. Parameter values are N0=4, N1=10−4, u=10−7, p0=10−6, p=10−2, τ0=10 days and τ1=1 day.)
| CIN genes | r | CIN before 1 TSG (%) | CIN before 2 TSGs (%) |
|---|---|---|---|
| n1=1 | 1.0 | 50 | 97 |
| 0.9 | 46 | 97 | |
| 0.5 | 21 | 88 | |
| n2=5 | 1.0 | 31 | 94 |
| 0.9 | 28 | 93 | |
| 0.5 | 11 | 76 | |
| n3=10 | 1.0 | 1.4 | 31 |
| 0.9 | 1.2 | 26 | |
| 0.5 | 0.4 | 7.7 |