Table 1.
Examples of genome-wide linkage studies in asthma.
| study | no. of subjects, populations | implicated chromosomes | phenotypes and remarks |
|---|---|---|---|
| Daniels et al. (1996) | 364, Western Australia; replication UK | 4, 6, 7, 11, 13, 16 | asthma, five related and subphenotypes |
| CSGA (1997) | 540, African–American, Caucasian, Hispanic | none for all populations. 2, 5, 11, 12, 13, 17, 19, 21 for one population each | asthma, bronchial hyperreactivity, atopy |
| Ober et al. (1998) | 653, Hutterites (USA) | 5q23–q31, 12q15–q24, 19q13, 21q21, 3p24–p22 | asthma and three related phenotypes |
| Wjst et al. (1999) | 415, mostly German | 2pter–p13, 6p21, 9q13–q32, 12q21 | asthma and six subphenotypes |
| Malerba et al. (1999) | 1083, North Italy | 12, 14 | asthma and three related phenotypes |
| Dizier et al. (2000) | 493, French (EGEA study) | 11p13, 12q24, 17q12–q21 | asthma and four related phenotypes |
| Laitinen et al. (2001) | Finnish, French Canadian | 7p | asthma, high IgE and their combination |
| Hakonarson et al. (2002) | 1134, Icelandic | 14q24 | asthma |
| Bouzigon et al. (2004) | 1355, French (EGEA study) | 6q14, 12p13, 17q22–q24, 21q21 | asthma and seven subphenotypes |