Table 2.

Positionally cloned asthma susceptibility genes for asthma.

study	gene name(s), chromosome	predicted primary function	suggested function in asthma	effect of polymorphisms
Van Eerdewegh et al. (2002)	ADAM33, 20p13	metalloproteinase	airway remodelling by fibroblasts and smooth muscle hyperreactivity	both amino acid substitutions and 3′ non-coding changes
Zhang et al. (2003)	PHF11, 13q14	zinc finger transcription factor	immuno-regulation, particularly B lymphocytes	non-coding. Regulation of alternative splicing?
Allen et al. (2003)	DPP10 (DRPR3), 2q14	dipeptidyl peptidase	cytokine processing, particularly T-lymphocytes	non-coding. Altered transcription factor binding to promoter, alternative splicing?
Laitinen et al. (2004)	GPRA (GPR154, PGR14, VRR1), 7p15	G-protein coupled receptor	bronchial epithelial and smooth muscle receptor	non-coding. Regulation of alternative splicing?