Table 3.
Replication studies for positionally cloned candidate genes in asthma.
| study, target gene | number of cases, populations | associated SNPs (no. of SNPs studied) | notes |
|---|---|---|---|
| Raby et al. (2004), ADAM33 | 549, US White, African American, US Hispanic | T1, T+1 (17) | associations only in US Hispanics. KL+1, V2, ST+7 were excluded as unreliable markers |
| Lee et al. (2004), ADAM33 | 326, Korean | none (5) | T1 associated with metacholine provocation |
| Howard et al. (2003), ADAM33 | 644, US White, African American, Dutch, US Hispanic | ST+7, V4 (8) | associated only in the Dutch |
| Lind et al. (2003), ADAM33 | 373, Mexico, Puerto Rico | none (6) | — |
| Jongepier et al. (2004), ADAM33 | 152, Dutch | S2 (8) | FEV decline as phenotype |
| Werner et al. (2004), ADAM33 | 91, German | ST+5, ST+7 (15) | — |
| Shin et al. (2004), GPRA | 439, Korean | none (1) | only 1 SNP genotyped |
| Melén et al. (2005), GPRA | 441, Austria, Germany, Netherlands, Sweden, Switzerland | rs324384, rs324396 (7) | haplotype associations in addition to SNP associations. Patients and controls are children |
| Kormann et al. (2005), GPRA | 624, German (3 centres) | SNP546333, SNP585883 (7) | haplotype associations in addition to SNP associations. Patients and controls are children |
Replication studies that consider the asthma phenotype have been published for ADAM33 and GPRA.