Table 4.

Examples of fine-mapping studies of PSORS1 to identify the psoriasis susceptibility gene.

study	number of subjects, population	number and type of markers	suggested limits of gene region
Oka et al. (1999)	208, Japanese	11 microsatellites	89–200 kb telomeric of HLA-C (incl. HCR, CDSN)
Nair et al. (2000)	1337, North American	62 microsatellites	30–90 kb telomeric of HLA-C (‘RH1’, excl. HCR and CDSN)
Asumalahti et al. (2002)	1049, six populations pooled	12 SNPs (for HLA-C, HCR, CDSN genes)	HLA-C and HCR indistinguishable, CDSN excluded
Veal et al. (2002)	667, UK European and Indian	59 SNPs	10 kb centromeric of HLA-C