Table 1.
Pharmacokinetic consequences of CYP2D6 polymorphism.
| pharmacokinetic parameter | consequences for the PM relative to EM |
|---|---|
| bioavailability | 2–5 fold |
| systemic exposure | |
| Cmax | 2–6 fold |
| AUC | 2–5 fold |
| half life | 2–6 fold |
| metabolic clearance | 0.1–0.5 fold |
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