Table 2.

Summary of cytokines and GVHD.

cytokine/growth factor	effects on GVHD	mechanism
IL-2, IL-12, IFN-γ	inhibits GVHD early	inhibits by activation-induced cell death of alloreactive T cells
promotes GVHD late	promotes by augmenting Th1 responses
IL4, IL10	predominantly inhibits GVHD	promotes Th2 responses and inhibits Th1
IL7	variable: no effect on or worsening of GVHD	augments T cell responses/thymopoiesis
KGF	protects from GVHD	promotes tissue repair
TNF	promotes GVHD	increases tissue destruction and inflammatory responses