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Metabolic flux in the Krebs cycle during oxidative stress when aconitase is completely inactivated. * Enzymes inhibited by H2O2. When aconitase, the most sensitive enzyme, is inhibited by 100% but α-KGDH is still functional in the presence of H2O2, a segment of the Krebs cycle (bold arrows) is maintained by glutamate, which is converted to α-ketoglutarate via transamination. This segment is inhibited only when α-KGDH is also inhibited by ROS. PDH, pyruvate dehydrogenase.
