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Nifedipine sensitivity of Ca2+ channel currents in PC12 cells. Mean (+s.e.m. bars) Ca2+ channel current–voltage (I–V) relationships obtained from PC12 cells before (filled circles) and during (open circles) bath application of 2 μM nifedipine. Cells were either cultured normoxically (a, n=10 cells), exposed to chronic hypoxia for 24 h (b, n=8), exposed to 100 nM AβP1–40 for 24 h (c, n=9), or to 100 nM AβP25–35 for 24 h (d, n=9).
